Longevity Protein Sir2

Extra copies of the gene called SIR2 - heterochromatin component - appears vital in longevity and are capable of extending the lifespan of both worms and flies. The mechanisms by which Sir2 homologues in higher organisms regulate lifespan is unclear, but the human SIRT1 protein has been demonstrated to deacetylate p53, Ku70, and the forkhead family of transcription factors. SIRT1 can also regulate acetylates such as CBP/p300, and has been shown to deacetylate specific histone residues.
Resveratrol, a polyphenol found in the skin of red grapes, has been also shown to extend the lifespan of yeast, worms, and flies.